2-Chlorodeoxyadenosine in psoriasis treatment
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چکیده
منابع مشابه
Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA).
We administered one course of 2-chlorodeoxyadenosine (2CdA) at 4 mg/m2 daily for 7 days by continuous intravenous infusion to 46 patients with hairy cell leukemia. Complete remissions occurred in 36 patients (78%; 95% confidence limits, 63% to 89%), partial remissions in five (11%), and a minor response in one. One patient died of candida sepsis 3 weeks after beginning treatment and three patie...
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3 4 3 encouraging results, we administered this agent to 10 patients with multiple myeloma staged according to standard criteria6; their clinical features are shown in Table 1. 2CdA was administered at a dose of 0.1 mg/kg/d for 7 days as a continuous infusion via a central venous catheter. Courses were repeated every 4 weeks. One patient received three courses, seven patients received two cours...
متن کامل2-Chlorodeoxyadenosine treatment for cutaneous T-cell lymphoma
The primary cutaneous lymphomas are often indolent but difficult to treat. In the early stages psoralen and ultraviolet-A therapy is the standard treatment whereas at the tumor stage chemotherapy (e.g. pegylated doxorubicin) is often used for debulking. The purine analog 2-chlorodeoxyadenosine (2CdA) acts in non-Hodgkin's lymphoma and has been used in our center for the treatment of advanced pr...
متن کامل2-Chlorodeoxyadenosine in the treatment of chronic refractory immune thrombocytopenic purpura.
Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder in which autoantibodies, most commonly against either the platelet glycoprotein (GP) IIb/Illa and/or GP Ib/lX complex, result in severe thrombocytopenia. Lasting complete and partial remissions are obtained in about 75% ofpatients with corticosteroids or splenectomy; refractory patients are usually treated with a variety of...
متن کامل2-Chlorodeoxyadenosine: an active agent in the treatment of cutaneous T-cell lymphoma.
Cutaneous T-cell lymphomas are disfiguring malignant lymphoproliferative disorders for which standard therapy has been principally palliative. 2-Chlorodeoxyadenosine (2-CdA), a new purine analogue resistant to degradation by adenosine deaminase that has substantial activity against lymphoid neoplasms, was administered to 16 patients with cutaneous involvement by T-cell lymphoma. All patients ha...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 1995
ISSN: 0923-7534
DOI: 10.1093/oxfordjournals.annonc.a059223